Hydroxyapatite from Cuttlefish Bone: Isolation, Characterizations, and Applications

摘要: Hydroxyapatite (HA), a bioceramic, is widely utilized material for bone tissue repair and regeneration because of its excellent properties such as biocompatibility, exceptional mechanical strength, osteoconductivity. HA can be obtained by both synthetic natural means. Animal bones are often considered promising resource the preparation pure biological biomedical applications. Cuttlefish bone, also called cuttlebone, mainly consists calcium carbonate, produced adding phosphoric acid or ammonium hydrogen phosphate to it. Recently, cuttlefish bone-derived has shown results in terms regeneration. The synthesized cell proliferation, increased alkaline activity, efficient biomineralization ability with mesenchymal stem cells osteoblastic cells. To further improve HA, bioglass, polycaprolactone, polyvinyl alcohol were added it, which gave better proliferation osteogenic differentiation. polymeric substances provides formation under vivo conditions. studies indicate that along and, protein materials, will biomaterials field