Emerging structural biology of TRPM subfamily channels
作者： Yixiang Chen , Xu Zhang , Tingting Yang , Ruixue Bi , Zhanmei Huang
DOI: 10.1016/J.CECA.2019.02.011
关键词: Neuroscience 、 TRPM 、 Transient receptor potential channel 、 Biology 、 Structural biology 、 Mechanism (biology) 、 Subfamily 、 Ion permeation 、 Ion channel
摘要: Abstract TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as potent entry point working desperate diseases out in new way with newfangled ideas and safer technological means. In our review, we discussed the common unique properties elaborate narrate their overall structures, different states underlying activation mechanism. Thus, this review can help to consummate limited work provide novel therapeutic targets certain diseases.
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