Antioxidant treatment prevents cognitive impairment and oxidative damage in pneumococcal meningitis survivor rats.

摘要: Pneumococcal meningitis is associated with the highest fatality case ratios in world. Most of patients that survive present neurologic sequelae at later times as well biochemicals alterations such oxidative stress both earlier and after central nervous system infection. In this context, we evaluated effect antioxidant treatment on memory parameters hippocampus survivor rats 10 days To aim, animals underwent a magna cistern tap receiving either μL sterile saline placebo or an equivalent volume Streptococcus pneumoniae suspension concentration 5x109 cfu/mL. The submitted to were divided into following groups: 1) treated antibiotic, 2) basic support plus N-acetylcysteine, 3) deferoxamine, 4) N-acetylcysteine 5) deferoxamine. Ten meningitis, inhibitory avoidance habituation open field tasks and, immediately after, assessed for damage cortex. group showed significantly decreased performance latency retention compared sham task. open-field task, presented impairment meningitis. All these impairments prevented by deferoxamine without its isolate use. addition, there was increase lipid phosphorylation cortex all combined antioxidants attenuated structures. On other hand, protein it. Thus, hypothesize may be related cognitive pneumococcal