Outbreak of Pseudomonas fluorescens bacteremia among oncology patients.

摘要: From 7 to 24 March 1997, four patients developed Pseudomonas fluorescens bacteremia at the hospital; one on oncology ward and other three in chemotherapy room. These all had underlying malignancies Port-A-Cath (Smiths Industries Medical Systems, Deltec, Inc., St. Paul, Minn.) implants. Three primary bacteremia, Port-A-Cath-related infection. None of these received a blood transfusion before episodes bacteremia. All recovered: two antimicrobial agents with vitro activity against isolates, did not have any antibiotic treatment. A total eight isolates were recovered from during febrile that occurred several minutes after infusion chemotherapeutic via Port-A-Cath. initially identified as P. or putida (four), Burkholderia (Ralstonia) pickettii (three), non-glucose-fermenting gram-negative bacillus (one) by routine biochemical methods Vitek GNI card. later basis characteristic cellular fatty acid chromatogram results supplemental tests. The identification identical antibiotypes E test random amplified polymorphic DNA patterns generated arbitrarily primed PCR showed outbreak was caused single clone fluorescens. Surveillance cultures possibly contaminated fluids disinfectants, which performed days recognition last infected patient, failed isolate This report small suggests timely, accurate unusual nosocomial pathogens is crucial for early initiation an epidemiological investigation timely control outbreak.