Innate Immune Response and Inflammation: Roles in Pathogenesis and Protection (Rickettsiaceae)

摘要: Although spotted fever group rickettsiae (SFGR) and typhus (TGR) represent two major antigenically defined historically well-known subdivisions of pathogenic Rickettsia species, recent in-depth characterization by neighbor-joining phylodendrogramic analysis has distributed into ancestral, fever, typhus, transitional subgroups. Importantly, well-established widely accepted in vivo models infection closely mimicking the pathogenesis Rocky Mountain (RMSF) epidemic humans employ susceptible mouse strains with conorii R. typhi, respectively. The endothelial cell responses to prowazekii signaling mechanisms that determine interplay between host unique rickettsial pathogen, which is capable escaping immune surveillance cause recrudescent infections, remain critically important but neglected areas scientific inquiry. Thus, one critical gaps understanding definition biological basis affinity consequent interactions vascular endothelium. rickettsii induces a biphasic pattern NF-ΚB activation cultured human cells characterized an early transient phase late sustained phase. There increasing recognition apoptosis, tightly regulated process altruistic suicide, plays central role complex invading pathogen defense. First recognized for their ability impede viral replication, interferons (IFNs) play determining survival response infection. During bacterial IFN defends integrating innate later events.