Intracellular Signaling: Mediators and Protective Responses

作者: Valina L. Dawson , Ted M. Dawson

DOI: 10.1016/B0-44-306600-0/50053-5

关键词: NeurotoxicityBiologyProgrammed cell deathCerebral blood flowIntracellularIn vivoBlood flowInjury mechanismsNeuroscienceNeuronal damage

摘要: The transient or permanent reduction in cerebral blood flow to a brain region results ischemic stroke and neurotoxicity. has relatively high consumption of oxygen glucose, which it requires continuous supply maintain normal function viability. Impairment the delivery glucose through reduced for even few minutes can trigger cascade events leading cell death. Thus, achievement both restoration control death cascades is important limit neuronal damage. It likely that successful treatment will be attainable near future as injury mechanisms are better understood vitro vivo experiments.

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