Genetically increased risk of sleep disruption in Alzheimer's disease.

摘要: Study objectives To investigate the role of a monoamine A oxidase promoter polymorphism in sleep disruption Alzheimer's disease (AD). Design case-control association analysis. Setting Sleep disturbance AD is common, extremely stressful for caregivers, and increases risk institutionalisation. It remains unclear why only some patients develop disturbance; neuropathologic changes are not typically seen areas brain responsible sleep. We hypothesized that is, at least part, influenced by availability serotonin used melatonin synthesis secondary to polymorphic variation enzyme (MAO-A). Patients with diagnosed according standard criteria. Interventions Data were collected using domain Neuropsychiatric Inventory Caregiver Distress. Patients' cognition function assessed Mini-Mental State Examination Functional Assessment Staging. Genotyping apolipoprotein E (APOE) 30 bp variable number tandem repeat MAO-A was methods. Measurements results Of 426 surveyed, 54% experienced disturbance. found high-activity 4-repeat allele VNTR confers increased susceptibility (p = .008). quantitative score significantly higher possessing genotypes. APOE had no influence on development an altered phenotype. Conclusions conclude common distressing associated genetic MAO-A.