Raman microscopy in the diagnosis and prognosis of surgically resected nonsmall cell lung cancer
作者： Nicholas David Magee , James Renwick Beattie , Chris Carland , Richard Davis , Kieran McManus
DOI: 10.1117/1.3323088
关键词: Lung cancer 、 Non small cell 、 Survival rate 、 Pathology 、 Lung 、 Carcinoma 、 Medicine 、 Microscopy 、 Cancer 、 Raman spectroscopy
摘要: The main curative therapy for patients with nonsmall cell lung cancer is surgery. Despite this, the survival rate only 50%, therefore it important to more efficiently diagnose and predict prognosis patients. Raman spectroscopy useful in diagnosis of malignant premalignant lesions. aim this study investigate ability microscopy from surgically resected tissue sections, these Tumor sections resections are mapped by spectra analzsed using multivariate techniques. Spectra tumor samples also compared their outcome data define prognostic significance. Using principal component analysis random forest classification, differentiates normal tissue. Principal 34 predicts early postoperative recurrence a sensitivity 73% specificity 74%. Spectral reveals elevated porphyrin levels DNA samples. can be technique receiving surgery, elucidating biochemical properties tumors.
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sci-hub.se 参考文章(37)
Hiro-o Hamaguchi, Hiroya Yamazaki, Ehiichi Kohda, Shoji Kaminaka, Makio Mukai, The diagnosis of lung cancer using 1064-nm excited near-infrared multichannel Raman spectroscopy. Radiation Medicine. ,vol. 21, pp. 1- 6 ,(2003)
Rodolfo Saracci, Markku Ahotupa, Carlo Giuntini, Stefano Petruzzelli, Maurizio Rindi, Laura Carrozzi, Gianfranco Menconi, Anne-Marie Camus, Helmut Bartsch, Carlo A. Angeletti, Antero Aitio, Eino Hietanen, Letizia Ghelarducci, Long-Lasting Effects of Tobacco Smoking on Pulmonary Drug-metabolizing Enzymes: A Case-Control Study on Lung Cancer Patients Cancer Research. ,vol. 48, pp. 4695- 4700 ,(1988)
Senada Koljenović, Tom C. Bakker Schut, Jan P. van Meerbeeck, Alexander P. W. M. Maat, Sjaak A. Burgers, Pieter E. Zondervan, Johan M. Kros, Gerwin J. Puppels, Raman microspectroscopic mapping studies of human bronchial tissue Journal of Biomedical Optics. ,vol. 9, pp. 1187- 1197 ,(2004) , 10.1117/1.1805555
Wilbur A. Franklin, Diagnosis of lung cancer: pathology of invasive and preinvasive neoplasia. Chest. ,vol. 117, ,(2000) , 10.1016/S0012-3692(15)38856-5
Nicholas Stone, Catherine Kendall, Jenny Smith, Paul Crow, Hugh Barr, None, Raman spectroscopy for identification of epithelial cancers Faraday Discussions. ,vol. 126, pp. 141- 157 ,(2004) , 10.1039/B304992B
M. V. P. Chowdary, K. Kalyan Kumar, Jacob Kurien, Stanley Mathew, C. Murali Krishna, Discrimination of normal, benign, and malignant breast tissues by Raman spectroscopy Biopolymers. ,vol. 83, pp. 556- 569 ,(2006) , 10.1002/BIP.20586
E. T. Cantrell, G. A. Warr, D. L. Busbee, R. R. Martin, Induction of Aryl Hydrocarbon Hydroxylase in Human Pulmonary Alveolar Macrophages by Cigarette Smoking Journal of Clinical Investigation. ,vol. 52, pp. 1881- 1884 ,(1973) , 10.1172/JCI107371
M. E. Garber, O. G. Troyanskaya, K. Schluens, S. Petersen, Z. Thaesler, M. Pacyna-Gengelbach, M. van de Rijn, G. D. Rosen, C. M. Perou, R. I. Whyte, R. B. Altman, P. O. Brown, D. Botstein, I. Petersen, Diversity of gene expression in adenocarcinoma of the lung Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 13784- 13789 ,(2001) , 10.1073/PNAS.241500798
C Murali Krishna, Gregory Kegelaer, Isabelle Adt, Sylvain Rubin, Vasudevan B Kartha, Michel Manfait, Ganesh D Sockalingum, None, Combined Fourier transform infrared and Raman spectroscopic approach for identification of multidrug resistance phenotype in cancer cell lines. Biopolymers. ,vol. 82, pp. 462- 470 ,(2006) , 10.1002/BIP.20485
Annette M. McWilliams, John R. Mayo, Myeong Im Ahn, Sharyn L.S. MacDonald, Stephen C. Lam, Lung Cancer Screening Using Multi-Slice Thin-Section Computed Tomography and Autofluorescence Bronchoscopy Journal of Thoracic Oncology. ,vol. 1, pp. 61- 68 ,(2006) , 10.1016/S1556-0864(15)31514-8