α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
作者： Gaozhi Chen , Yang Liu , Regina Goetz , Lili Fu , Seetharaman Jayaraman
DOI: 10.1038/NATURE25451
关键词: Signal transduction 、 Protein domain 、 Fibroblast growth factor receptor 、 Cell biology 、 Heparan sulfate 、 Scaffold protein 、 Paracrine signalling 、 Ternary complex 、 Chemistry 、 Fibroblast growth factor
摘要: … α-klotho ecto can serve as a co-receptor for FGF23. Pre-treatment of HEK293-α-klotho TM cells with α-klotho … this cell line were in binary FGFR–α-klotho TM form (Extended Data Fig. 1b, …
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