Biosynthesis of artemisinin in Artemisia annua
作者： Anand Akhila , Raghunath S. Thakur , Satya P. Popli
DOI: 10.1016/S0031-9422(00)81731-8
关键词: Artemisia annua 、 Sesquiterpene 、 Biosynthesis 、 Yield (chemistry) 、 Stereochemistry 、 Chemistry 、 Arteannuin B 、 Artemisinin
摘要: Abstract The isotope ratios ( 3 H: 14 C) in arteannuin B and artemisinin biosynthesized Artemisia annua from [4 R - H 1 ,2- C]-, [5- 2 C]- [2- C](3 RS )- mevalonate have revealed that two specific 1,2-hydride shifts take place during the oxidation lactonization of germacrane skeleton to yield dihydrocostunolide. gem -methyls DMAPP retain their identity until final steps biosynthesis. Arteannuin is considered be a late precursor following biosynthetic sequence suggested: farnesylpyrophosphate → dihydrocostunolide cadinanolide artemisinin.
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