Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part I: histopathological alterations and bioaccumulation in rainbow trout☆

作者: J. Schwaiger , H. Ferling , U. Mallow , H. Wintermayr , R.D. Negele

DOI: 10.1016/J.AQUATOX.2004.03.014

关键词: DiclofenacToxicityPharmacologyToxicologyHyalineGillBioaccumulationMuscle tissueNecrosisBiologyKidney

摘要: … of the capillary wall within the secondary lamellae. The lowest observed effect concentration (… evaluate possible long-term effects of diclofenac on the health status of fish as a non-target …

参考文章(52)
Julia Schwaiger, Rüdiger Wanke, Stefan Adam, Michael Pawert, Wolfgang Honnen, Rita Triebskorn, The use of histopathological indicators to evaluate contaminant-related stress in fish Journal of Aquatic Ecosystem Stress and Recovery. ,vol. 6, pp. 75- 86 ,(1997) , 10.1023/A:1008212000208
Singh I, A MODIFICATION OF THE MASSON-HAMPERL METHOD FOR STAINING OF ARGENTAFFIN CELLS. Anatomischer Anzeiger. ,vol. 115, pp. 81- ,(1964)
Rita Triebkorn, H. -R. K�hler, Plasticity of the endoplasmic reticulum in three cell types of slugs poisoned by molluscicides Protoplasma. ,vol. 169, pp. 120- 129 ,(1992) , 10.1007/BF01323611
J Hart, M O Blackstone, F Baert, A case of diclofenac-induced colitis with focal granulomatous change. The American Journal of Gastroenterology. ,vol. 90, pp. 1871- 1873 ,(1995)
M Zeitz, A Stallmach, H Hackstein, W Püschel, W Mohl, [Diclofenac-associated acute cholestatis hepatitis]. Zeitschrift Fur Gastroenterologie. ,vol. 36, pp. 385- 389 ,(1998)
Frank Sacher, Frank Thomas Lange, Heinz-Jürgen Brauch, Iris Blankenhorn, Pharmaceuticals in groundwaters analytical methods and results of a monitoring program in Baden-Württemberg, Germany. Journal of Chromatography A. ,vol. 938, pp. 199- 210 ,(2001) , 10.1016/S0021-9673(01)01266-3
Révai T, Harmos G, Nephrotic syndrome and acute interstitial nephritis associated with the use of diclofenac. Wiener Klinische Wochenschrift. ,vol. 111, pp. 523- 524 ,(1999)
Anil Bhogaraju, Syed Nazeer, Yasser Al-Baghdadi, Mohammed Rahman, Frank Wrestler, Nalin Patel, None, Diclofenac-associated hepatitis. Southern Medical Journal. ,vol. 92, pp. 711- 713 ,(1999) , 10.1097/00007611-199907000-00011
Maike Gernhöfer, Michael Pawert, Michael Schramm, Ewald Müller, Rita Triebskorn, Ultrastructural biomarkers as tools to characterize the health status of fish in contaminated streams Journal of Aquatic Ecosystem Stress and Recovery. ,vol. 8, pp. 241- 260 ,(2001) , 10.1023/A:1012958804442