Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE

作者: George C Tsokos , Madhusoodana P Nambiar , Klaus Tenbrock , Yuang-Taung Juang

DOI: 10.1016/S1471-4906(03)00100-5

关键词: Fc receptorResponse elementReceptorTranscription factorMolecular biologyImmunologyTranscription (biology)Tyrosine phosphorylationRepressorBiologyT cell

摘要: … SLE T-cell responses. Two observations were made in this set of experiments: first, the endogenous ζ chain was decreased (both mRNA and protein) and second, the phosphorylated …

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