Influence of hesperidin and vitamin C on glycemic parameters, lipid profile, and DNA damage in rats treated with sucrose overload.
作者： Silvia IR Franke , Patrícia Molz , Camila Mai , Joel H Ellwanger , Fernanda F Zenkner
DOI: 10.1590/0001-3765201820170751
关键词: Hesperidin 、 Internal medicine 、 Comet assay 、 Sucrose 、 Vitamin C 、 Chemistry 、 Lipid profile 、 DNA damage 、 Endocrinology 、 Ascorbic acid 、 Glycated hemoglobin
摘要: We evaluated the influence of hesperidin and vitamin C (VitC) on glycemic parameters, lipid profile, DNA damage in male Wistar rats treated with sucrose overload. Rats were divided into six experimental groups: I-water control; II-sucrose III-hesperidin IV-VitC V-co-treatment plus hesperidin; VI-co-treatment VitC. measured levels triglycerides, total cholesterol, HDL-c, LDL-c, fasting glucose, glycated hemoglobin (A1C). was blood brain cells using comet assay micronucleus test used to evaluate chromosomal damages rat bone marrow. Co-treatment VitC, but not hesperidin, normalized serum glucose. No effect co-treatments observed A1C. The co-treatment VitC or did profile (p>0.05). co-treated had a significantly lower level (p 0.05). Hesperidin showed different effects levels. While lowered reduced damage.
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