THE EFFECT OF ATRACTYLATE AND OLIGOMYCIN ON THE BEHAVIOUR OF MITOCHONDRIA TOWARDS ADENINE NUCLEOTIDES.
作者： JB CHAPPELL , AR CROFTS
DOI: 10.1042/BJ0950707
关键词: Oxidative phosphorylation 、 Biochemistry 、 Nicotinamide 、 Dephosphorylation 、 Oligomycin 、 Adenosine triphosphate 、 Adenine nucleotide 、 Nucleotide 、 Phosphorylation 、 Biology
摘要: 1. Investigation of a number reactions involving both internal and externally added adenine nucleotides isolated liver mitochondria has revealed that atractylate oligomycin differ markedly in the site their inhibitory action. 2. Both inhibited respiratory-chain-level phosphorylation ADP. Neither compound substrate-level (endogenous) ADP or respiration-dependent accumulation bivalent metal ions (Ca(2+), Sr(2+) Mn(2+)). 3. Atractylate, but not oligomycin, ADP, ATP- carnitine-dependent reduction nicotinamide nucleotide by palmitate ATP-induced activation succinate oxidation. 4. Oligomycin, atractylate, respiratory-chain-linked dephosphorylation ATP occurred on addition antimycin. 5. The enhancement arsenate-stimulated respiration was prevented either before after Oligomycin abolished arsenate stimulation. 6. It is suggested prevents passage across mitochondrial membrane, whereas interferes with formation ;high-energy' phosphorylated intermediate.
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