Chromosomal changes in relation to clinical outcome in larynx and pharynx squamous cell carcinoma.

摘要: Invasive head and neck squamous carcinomas are among the cytogenetically most complex tumors. Perhaps for this reason, there is little consensus on prognostic value of specific chromosomal aberrations. Here we present Results CGH analysis 56 clinically well-characterized set cancers, consisting larynx pharynx only. The aim was to find possible associations with clinical outcome. major chromosome arms showing gains were (in decreasing order): 3q, 7q, 8q, 5p, 11q13, 17q 18p, losses occurred at 3p, 11qter, 4p, 18q, 5q. segments frequently amplified 3q26-qter, 11q22, 3q12–13, 18p11.3, 18q11.2 8q24.3. Tumors stages III IV, lymph node positive tumors had a worse Surprisingly, no abnormality correlated disease-free survival. only aberration that one clinico-pathological parameters amplification solely in positive, stage IV However 11q13 did not correlate These seem indicate genetic alterations level chromosomes have limited patients invasive cell carcinomas.