Altered Posterior Midline Activity in Patients with Jerky and Tremulous Functional Movement Disorders.

摘要: Objective: To explore changes in resting-state networks patients with jerky and tremulous functional movement disorders (JT-FMD). Methods: Resting-state magnetic resonance imaging data from seventeen JT-FMD age-, sex-, education-matched healthy controls (HC) were investigated. Independent component analysis was used to examine the central executive network (CEN), salience network, default mode (DMN). Frequency distribution of signal fluctuations intra- internetwork connectivity Symptom severity measured using Clinical Global Impression-Severity scale. Beck Depression Inventory Anxiety scores collected measure depression anxiety FMD, respectively. Results: Compared HC, had significantly decreased power lower range (0.01-0.10 Hz) frequency a precuneus posterior cingulate cortex DMN dorsal attention (DAN) CEN (false discovery rate-corrected p < 0.05). No significant group differences found for connectivity. In JT-FMD, symptom not correlated measures. weakly intranetwork medial prefrontal cortex, while be related Conclusions: Given posterodorsal components DAN, we postulate that JT-FMD-related alterations these regions could provide support concept particularly attentional dysregulation is fundamental disturbance patients.