SEVERE RADIATION MORBIDITY IN CARCINOMA OF THE CERVIX: IMPACT OF PRETHERAPY SURGICAL STAGING AND PREVIOUS SURGERY

摘要: Abstract Purpose: The purpose of this study is to delineate the factors which (a) contribute an increase in severe, radiation induced complication rate and (b) have a significant effect on survival patients with International Federation Gynecologists Obstetricians (FIGO) Stage I–IVA cervical cancer undergoing pretherapy surgical staging. Methods Materials: From 1971–1991, 189 underwent staging via retroperitoneal approach (67) or transperitoneal (122). Seventy-nine had previously experienced laparotomy. Patients subsequently received median 85 Gy point A. In receiving paraaortic radiation, 45 was administered. One hundred thirty-two (69.8%) hydroxyurea as sensitizer. Results: Pretherapy evaluation revealed that 21 89 (23.6%) II 32 (37.6%) III lymph node metastases. Multivariate logistic regression analysis detailed favorably influencing radiation-induced be no previous Survival significantly prolonged hydroxyurea, evaluated incision, negative nodes, early stage disease. Conclusion: A absence surgery reduced incidence subsequent complications. Despite improvements detection occult disease, impaired when therapeutic measures currently available are used.