Combined cyclophosphamide, vincristine, and prednisone therapy of malignant lymphoma
作者： James K. Luce , Jess F. Gamble , Henry E. Wilson , Raymond W. Monto , Bertha L. Isaacs
DOI: 10.1002/1097-0142(197108)28:2<306::AID-CNCR2820280208>3.0.CO;2-N
关键词: Prednisone 、 Follicular lymphoma 、 Prior Therapy 、 Internal medicine 、 Immunology 、 Gastroenterology 、 Vincristine 、 Malignant lymphoma 、 Cyclophosphamide 、 Chemotherapy 、 Medicine 、 Radiation therapy 、 Cancer research 、 Oncology
摘要: A combination of intravenous cyclophosphamide and vincristine (Oncovin) oral prednisone (COP) was given every 2 weeks to 262 patients with disseminated Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, follicular lymphoma. complete remission produced in 36% 50% 39% sarcoma. These rates are significantly superior those by single agents. Patients who achieved a were randomly allocated monthly COP (maintained remission) or no treatment (unmaintained remission). The median duration maintained longer than unmaintained for disease (42 vs. 19 weeks) lymphosarcoma (49 21 but not sarcoma (24 25 weeks). little prior therapy compared that similar study which agents used.4 For remissions cyclophosphamide. after induction agent induction. All parameters response, is, rate, remission, survival adversely affected major radiotherapy chemotherapy. initial response correlated positively survival. receiving comparable group treated sequentially
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