Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania.
作者： Inge Kroidl , Petra Clowes , Klaus Reither , Bariki Mtafya , Gabriel Rojas-Ponce
DOI: 10.1183/09031936.00003315
关键词: Prospective cohort study 、 Tuberculosis diagnosis 、 Excretion 、 Tuberculosis 、 Gastroenterology 、 Proteinuria 、 Immunology 、 Incidence (epidemiology) 、 Medicine 、 Urine 、 Lipoarabinomannan 、 Internal medicine
摘要: We evaluated the diagnostic performance of two tests based on release lipoarabinomannan (LAM) into urine, MTB-LAM-ELISA assay and Determine TB-LAM-strip assay, in children with suspected tuberculosis (TB) a high TB/HIV-prevalence setting.In prospective study, 132 active TB were assigned to subgroups. Urine samples subjected testing by both assays ascertain sensitivity specificity. Host factors associated positive LAM results investigated excretion monitored after antituberculous treatment initiation.18 (13.6%) had culture-confirmed pulmonary TB. The assays' was higher HIV-positive versus HIV-negative children: 70% (95% confidence interval 35-93%) 13% (0-53%) for 50% (19-81%) 0% (0-37%) TB-LAM. In 35 (27%) excluded TB, showed specificity 97.1% (85-100%). Proteinuria low body mass index independently positivity. most patients, declined zero during or at conclusion treatment.HIV/TB co-infected might benefit from LAM-based aid early diagnosis subsequent impact morbidity mortality. Using as rule-in treatment-monitoring tool may also show further potential.
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