The Big Book of Aldehyde Dehydrogenase Sequences
作者： John Perozich , Hugh Nicholas , Ronald Lindahl , John Hempel
DOI: 10.1007/978-1-4615-4735-8_1
关键词: Sequence identity 、 Mitochondrial Aldehyde Dehydrogenase 、 Aldehyde dehydrogenase 、 ALDH Family 、 Chemistry 、 Biochemistry
摘要: Traditionally, research on aldehyde dehydrogenases (ALDHs, EC 1.2.1) has focused three groups: class 1, 2, and 3 ALDHs. Class 1 2 ALDHs are very closely related homotetramers both participate in ethanol metabolism, though can oxidize wide range of metabolites, including retinal (reviewed Lindahl, 1982; Yoshida et al., 1). appear at first glance to be highly divergent from the other classes. share only about 25% sequence identity with homodimers. However, main-chain folding, structures monomers nearly identical (Hempel 1999)
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