The Function of GPI-Anchored Proteins
作者： Ian Okazaki , Joel Moss
DOI: 10.1016/B978-012772940-4/50008-6
关键词: Biology 、 Peripheral membrane protein 、 Membrane protein 、 Biochemistry 、 GTPase-activating protein 、 Signal transduction 、 14-3-3 protein 、 Transmembrane protein 、 Cell signaling 、 Cell biology 、 Diacylglycerol kinase
摘要: Publisher Summary Although proteins attached to the plasma membrane through a glycosylphosphatidylinositol (GPI) linkage are certainly diverse, these now appear use common signaling pathways. This chapter discusses role of GPI-anchored (GPI-AP) in cell function. GPI-linked can be released from surface by phospholipases C and D generate molecules diacylglycerol phosphatidic acid. Some effects insulin may mediated this manner. The association GPI-AP with members src-family protein tyrosine kinases is established, following antibody cross-linking T antigens. It unclear whether antibodies vitro analogous ligand binding vivo. Molecules GPI anchors that do not span lipid bilayer assumed form an obligatory complex transmembrane transmit extracellular signals intracellular effectors. Many enzymes. ectoenzyme activity on function have often seemed independent signaling.
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