Autoantibody to a Nuclear Antigen in Proliferating Cells

摘要: This study reports the identification of an autoantibody in sera some patients with systemic lupus erythematosus that reacted nuclear antigen(s) proliferating cells. The was initially detected by observation it did not react immunofluorescence nuclei renal tubular or glomerular cells, nor hepatic parenchymal but only scattered cells interstitial tissue these two organs. In contrast, many lymphocytes lymph node follicles, spleen, and thymus this antinuclear antibody. Normal peripheral blood show staining after mitogenic stimulation, 20% became positive. Nuclear restricted to also observed several culture lines such as Hep-2 (human epithelial carcinoma), Ehrlich ascites tumor baby hamster kidney reactive soluble physiologic saline serum give a precipitin line immunodiffusion immunologically distinct from DNA other known antigen-antibody precipitating systems. Autoantibodies cell might serve useful biologic markers stimulated