The association between polymorphisms in RLIP76 and drug response in epilepsy.
作者： Guy D Leschziner , Andrea L Jorgensen , Toby Andrew , Paula R Williamson , Anthony G Marson
DOI: 10.2217/14622416.8.12.1715
关键词: Genotype 、 Pharmacology 、 Genotyping 、 Retrospective cohort study 、 Epilepsy 、 Medicine 、 Multiple drug resistance 、 Drug resistance 、 Drug response 、 Prospective cohort study 、 Internal medicine
摘要: Introduction: Approximately 30% of patients with epilepsy are resistant to treatment with anti-epileptic drugs (AEDs). The ABC drug transporter proteins are hypothesized to mediate drug …
futuremedicine.com
sci-hub.se 
researchgate.net 参考文章(17)
Sanjay Awasthi, Kerri L Hallene, Vince Fazio, Sharad S Singhal, Luca Cucullo, Yogesh C Awasthi, Gabriele Dini, Damir Janigro, RLIP76, a non-ABC transporter, and drug resistance in epilepsy BMC Neuroscience. ,vol. 6, pp. 61- 61 ,(2005) , 10.1186/1471-2202-6-61
Andrew Owen, Munir Pirmohamed, Justice N Tettey, Paul Morgan, David Chadwick, B Kevin Park, None, Carbamazepine is not a substrate for P-glycoprotein. British Journal of Clinical Pharmacology. ,vol. 51, pp. 345- 349 ,(2001) , 10.1046/J.1365-2125.2001.01359.X
Nigel CK Tan, Samuel F Berkovic, Prediction of drug resistance in epilepsy: not as easy as ABC Lancet Neurology. ,vol. 5, pp. 641- 642 ,(2006) , 10.1016/S1474-4422(06)70505-1
Douglas G Altman, Patrick Royston, The cost of dichotomising continuous variables BMJ. ,vol. 332, pp. 1080- 1080 ,(2006) , 10.1136/BMJ.332.7549.1080
Graeme J. Sills, Rajiv Mohanraj, Elaine Butler, Sheila McCrindle, Lindsay Collier, Elaine A. Wilson, Martin J. Brodie, Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment Epilepsia. ,vol. 47, pp. 643- 647 ,(2006) , 10.1111/J.1528-1167.2005.46304.X
N. C.K. Tan, S. E. Heron, I. E. Scheffer, J. T. Pelekanos, J. M. McMahon, D. F. Vears, J. C. Mulley, S. F. Berkovic, Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Neurology. ,vol. 63, pp. 1090- 1092 ,(2004) , 10.1212/01.WNL.0000137051.33486.C7
F. Zimprich, R. Sunder-Plassmann, E. Stogmann, A. Gleiss, A. Dal-Bianco, A. Zimprich, S. Plumer, C. Baumgartner, C. Mannhalter, Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Neurology. ,vol. 63, pp. 1087- 1089 ,(2004) , 10.1212/01.WNL.0000141021.42763.F6
G D Leschziner, T Andrew, M Pirmohamed, M R Johnson, ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenomics Journal. ,vol. 7, pp. 154- 179 ,(2007) , 10.1038/SJ.TPJ.6500413
Guy Leschziner, Andrea L Jorgensen, Munir Pirmohamed, Paula R Williamson, Anthony G Marson, Alison J Coffey, Claire Middleditch, Jane Rogers, David R Bentley, David W Chadwick, David J Balding, Michael R Johnson, Toby Andrew, Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study Lancet Neurology. ,vol. 5, pp. 668- 676 ,(2006) , 10.1016/S1474-4422(06)70500-2
Wolfgang Löscher, Heidrun Potschka, Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases Progress in Neurobiology. ,vol. 76, pp. 22- 76 ,(2005) , 10.1016/J.PNEUROBIO.2005.04.006