Cation translocating effects of alamethicin and its synthetic fragments in lipid membranes: Influence of peptide chain length and charge
作者： R. Nagaraj , M.K. Mathew , P. Balaram
DOI: 10.1016/0014-5793(80)80383-8
关键词: Peptide 、 Stereochemistry 、 Alamethicin 、 Ionophore 、 Membrane 、 Residue (chemistry) 、 Transmembrane channels 、 Chain length 、 Chemistry 、 Membrane channel
摘要: Alamethicin, a 20 residue polypeptide ionophore forms transmembrane channels and has been shown to induce excitability phenomena in artificial lipid membranes [1]. The discovery of number related polypeptides, containing \alpha-aminoisobutyric acid (Aib) [2], stimulated considerable interest the conformational analysis Aib peptides, with view towards establishing structural requirements for formation membrane [3-5].
elsevier.com
sci-hub.se 参考文章(17)
H. H. Ussing, Membrane Transport in Biology ,(2011)
Günther Jung, Wilfried A. König, Dieter Leibfritz, Tadaaki Ooka, Karl Janko, Günther Boheim, Structural and membrane modifying properties of suzukacillin, a peptide antibiotic related to alamethicin. Part A. Sequence and conformation. Biochimica et Biophysica Acta. ,vol. 433, pp. 164- 181 ,(1976) , 10.1016/0005-2736(76)90185-1
Tetsuro Fujita, Yoshihisa Takaishi, Takaaki Shiromoto, New peptide antibiotic, hypelcin a, from hypocrea peltata Journal of The Chemical Society, Chemical Communications. pp. 413- 414 ,(1979) , 10.1039/C39790000413
Gerhard Irmscher, Günter Bovermann, Günther Boheim, Günther Jung, Trichotoxin A-40, a new membrane-exciting peptide. Part A. Isolation, characterization and conformation Biochimica et Biophysica Acta. ,vol. 507, pp. 470- 484 ,(1978) , 10.1016/0005-2736(78)90356-5
Moisés Eisenberg, James E. Hall, C. A. Mead, The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes. The Journal of Membrane Biology. ,vol. 14, pp. 143- 176 ,(1973) , 10.1007/BF01868075
J Brunner, P Skrabal, H Hausser, Single bilayer vesicles prepared without sonication physico-chemical properties Biochimica et Biophysica Acta. ,vol. 455, pp. 322- 331 ,(1976) , 10.1016/0005-2736(76)90308-4
PAUL MUELLER, DONALD O. RUDIN, Action Potentials induced in Biomolecular Lipid Membranes Nature. ,vol. 217, pp. 713- 719 ,(1968) , 10.1038/217713A0
R. Nagaraj, P. Balaram, Fluorescent hydrophobic peptide fragments of emerimicin. Models for the study of peptide aggregation and interactions with lipids and proteins Biochemical and Biophysical Research Communications. ,vol. 89, pp. 1041- 1049 ,(1979) , 10.1016/0006-291X(79)92113-2
A.H. Caswell, J.D. Hutchison, Visualization of membrane bound cations by a fluorescent technique Biochemical and Biophysical Research Communications. ,vol. 42, pp. 43- 49 ,(1971) , 10.1016/0006-291X(71)90359-7
A.H. Caswell, J.D. Hutchison, Selectivity of cation chelation to tetracyclines: Evidence for special conformation of calcium chelate Biochemical and Biophysical Research Communications. ,vol. 43, pp. 625- 630 ,(1971) , 10.1016/0006-291X(71)90660-7