EARLY AGGRESSIVE ANTIHYPERTENSIVE TREATMENT REDUCES RATE OF DECLINE IN KIDNEY FUNCTION IN DIABETIC NEPHROPATHY
作者： Hans-Henrik Parving , UllaM Smidt , AllanR Andersen , PerAa Svendsen
DOI: 10.1016/S0140-6736(83)92462-5
关键词: Endocrinology 、 Metoprolol 、 Furosemide 、 Diabetic nephropathy 、 Renal function 、 Urology 、 Blood pressure 、 Internal medicine 、 Excretion 、 Thiazide 、 Hydralazine 、 Medicine
摘要: Abstract The effect of early aggressive antihypertensive treatment on kidney function in diabetic nephropathy was studied prospectively ten insulin-dependent diabetics (mean age 29 years). During the mean pretreatment period (range 23-38) months glomerular filtration rate (GFR) decreased significantly and urinary albumin excretion arterial blood pressure rose significantly. 39 month 28-48) with metoprolol, hydralazine, frusemide (furosemide) or thiazide, fell from 144/97 mm Hg all values) to 128/84 post-treatment values), 977 μg/min 433 μg/min, GFR 80 62 ml/min/L·73 m 2 . decline 0·91 ml/min/month before 0·39 0·08 0·68 ml/min/month) during treatment.
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