Expression pattern of delta-like 1 homolog in developing sympathetic neurons and chromaffin cells.

摘要: Delta-like 1 homolog (DLK1) is a member of the epidermal growth factor (EGF)-like family and an atypical notch ligand that widely expressed during early mammalian development with putative functions in regulation cell differentiation proliferation. During later stages development, DLK1 downregulated becomes increasingly restricted to specific types, including several types endocrine cells. has been linked various tumors associated tumor stem features. Sympathoadrenal precursors are neural crest derived cells give rise either sympathetic neurons autonomic nervous system or chromaffin located adrenal medulla extraadrenal positions. As these cellular origin neuroblastoma, one most common malignant childhood, their molecular characterization high clinical importance. In this study we have examined precise spatiotemporal expression developing sympathoadrenal We show mRNA highly neuron progenitors its depends on presence Phox2B. quickly small subpopulation ganglia, while virtually all Organ Zuckerkandl still express levels at late gestational stages.