Occurrence of Phosphenes in Patients Undergoing Proton Beam Therapy for Ocular Tumor
作者： Thibaud Mathis , Petter Hofverberg , Jean-Pierre Caujolle , Joël Hérault , Cécilia Leal
DOI: 10.1016/J.AJO.2018.05.006
关键词: Optic disc 、 Ocular Tumor 、 Young age 、 Retinal ganglion 、 Single Center 、 Phosphene 、 In patient 、 Ophthalmology 、 Prospective cohort study 、 Medicine
摘要: PURPOSE Phosphenes are frequently reported by patients irradiated in the head and neck area. The aim of present study was to characterize investigate potential mechanisms proton beam therapy (PBT)-induced phosphenes a large population undergoing PBT for ocular tumors. DESIGN Prospective cohort study. METHODS Consecutive who underwent single center were included. Immediately after first session, all completed questionnaire collecting information about presence as well their color, shape, duration. Patient, tumor treatment characteristics (dose volume histograms) also collected. RESULTS Among 474 included, 62.8% during session PBT. Reported colors mainly blue-violet (70.5%) white (14.1%). prevalence higher younger (P = .003); other patient or not associated with occurrence phosphenes. Irradiation macula (P < .001) and/or optic disc significantly phosphenes, whereas color only young age irradiation macular area .04). Pupillary constriction 57.1% vs 18.5% without .001). Blue-violet statistically pupillary constriction. CONCLUSIONS high rate tumor. Their association probably indicates stimulation S-cones retinal ganglion cells that reflects activation afferent visual pathway.
sci-hub.se 参考文章(43)
Livio Narici, Christer Fuglesang, Walter G. Sannita, Piergiorgio Picozza, Phosphenes in low earth orbit: survey responses from 59 astronauts. Aviation, Space, and Environmental Medicine. ,vol. 77, pp. 449- 452 ,(2006)
Gerald J. Chader, James Weiland, Mark S. Humayun, Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Progress in Brain Research. ,vol. 175, pp. 317- 332 ,(2009) , 10.1016/S0079-6123(09)17522-2
Lan Yue, Paulo Falabella, Punita Christopher, Varalakshmi Wuyyuru, Jessy Dorn, Paulo Schor, Robert J. Greenberg, James D. Weiland, Mark S. Humayun, Ten-Year Follow-up of a Blind Patient Chronically Implanted with Epiretinal Prosthesis Argus I Ophthalmology. ,vol. 122, pp. 2545- 2552 ,(2015) , 10.1016/J.OPHTHA.2015.08.008
Yvonne Hsu-Lin Luo, Lyndon da Cruz, The Argus(®) II Retinal Prosthesis System. Progress in Retinal and Eye Research. ,vol. 50, pp. 89- 107 ,(2016) , 10.1016/J.PRETEYERES.2015.09.003
Frank Wilcoxon, Individual Comparisons by Ranking Methods Springer Series in Statistics. ,vol. 1, pp. 196- 202 ,(1992) , 10.1007/978-1-4612-4380-9_16
Sara Garcia, Karin Petrini, Gary S. Rubin, Lyndon Da Cruz, Marko Nardini, Visual and Non-Visual Navigation in Blind Patients with a Retinal Prosthesis. PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0134369
Christopher A. Procyk, Cyril G. Eleftheriou, Riccardo Storchi, Annette E. Allen, Nina Milosavljevic, Timothy M. Brown, Robert J. Lucas, Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones. Journal of Neurophysiology. ,vol. 114, pp. 1321- 1330 ,(2015) , 10.1152/JN.00368.2015
L Cervetto, G C Demontis, C Gargini, Cellular mechanisms underlying the pharmacological induction of phosphenes British Journal of Pharmacology. ,vol. 150, pp. 383- 390 ,(2007) , 10.1038/SJ.BJP.0706998
Walter G. Sannita, Livio Narici, Piergiorgio Picozza, Positive visual phenomena in space: A scientific case and a safety issue in space travel Vision Research. ,vol. 46, pp. 2159- 2165 ,(2006) , 10.1016/J.VISRES.2005.12.002
Raymond O. Beirne, Margarita B. Zlatkova, Chin-Kuo Chang, Usha Chakravarthy, Roger S. Anderson, How does the short-wavelength-sensitive contrast sensitivity function for detection and resolution change with age in the periphery? Vision Research. ,vol. 48, pp. 1894- 1901 ,(2008) , 10.1016/J.VISRES.2008.05.024