Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study.

摘要: Background— Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T1 mapping is a previously validated technique that can quantify the burden of global and regional fibrosis. However, association between MRI subtle left ventricular (LV) dysfunction in diabetic unknown. Methods Results— Fifty with normal LV ejection fraction (EF) no underlying coronary artery disease or macroscopic scar delayed enhancement were prospectively recruited. compared 19 healthy controls who frequency matched age, sex body mass index. There significant differences mean end-diastolic volume index, end-systolic index LVEF controls. had significantly shorter contrast-enhanced time (425±72 ms vs. 504±34 ms, P <0.001). was correlation ( r =0.14, =0.32) patients. there good longitudinal strain =−0.73, Global strongest independent determinant multivariate analysis (standardized β=−0.626, Similarly, septal E′ =0.54, also β=0.432, <0.001). Conclusions— A associated more impaired systolic diastolic function