High progesterone levels adversely affect embryo quality and pregnancy rates in in vitro fertilization and oocyte donation programs.

摘要: Objective To assess the effect of P levels on oocyte and embryo quality pregnancy rates (PRs) in IVF donation. Design Retrospective analysis PRs ovum donors their recipients with regard to day hCG administration. Setting In Vitro Fertilization Units, donation programs. Patients vitro fertilization patients who agreed donate oocytes were treated by hMG alone (53 cycles) or combination a GnRH analog (122 cycles). Interventions Uterine preparation consisted 6 mg/d E 2 valerate. Progesterone (100 mg/d) was added when became available. Hormonal treatment continued until 12 weeks gestation. Results Using series Fisher's Exact Tests, critical threshold for identified at 1.9 ng/mL (conversion factor SI units, 3.185). With elevated (>1.9 ng/mL), lower noted (7.1% versus 17%), as well (8.3% 26.7%). Conclusions Exposure resulted significantly recipients. Because endometria prepared uniformly, we conclude that this is result detrimental effects quality.