LIPID NANOPARTICLE FORMULATIONS COMPRISING NUCLEIC ACID MIMICS
作者： Ying Bo , Sim Derek
DOI:
关键词: Nanoparticle 、 Nucleic acid 、 Biochemistry 、 Intracellular 、 Genome editing 、 Chemistry
摘要: Described herein are lipid nanoparticles (LNPs), comprising neutral or positively charged nucleic acid mimics (NPNAMs) and optionally acids, compositions thereof. Also described methods of preparing LNPs NPNAMs, use for intracellular gene editing. In particular, the NPNAMs acids may be used in correction and/or treatment a genetic disorder, disease, condition subject.
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