Gut-derived Serotonin and Bone Formation

作者: Patricia Ducy

DOI: 10.1016/B978-0-12-415784-2.00007-5

关键词: Bone remodelingOsteoporosisSerotonin ProductionAnabolismTryptophan hydroxylaseInternal medicineSerotoninBiologyEndocrinologyOsteoblastPhenotype

摘要: Adding to the ever-growing list of molecules involved in regulating bone remodeling, gut-derived serotonin was recently shown specifically control formation side this process. Indeed, mice deficient tryptophan hydroxylase 1, rate-limiting enzyme controlling production by gut cells, have a high mass phenotype caused solely increased osteoblast proliferation. Furthermore, when treated with inhibitor able decrease synthesis, and rats display an increase that is sufficient counterbalance loss induced ovariectomy long bones as well vertebrae. Importantly, low levels circulating also been correlated with, respectively, decreased humans. These findings raise prospect pharmacologically manipulating could become novel strategy treat disorders such osteoporosis through anabolic approach.

参考文章(108)
Marcel Wehrli, Scott T. Dougan, Kim Caldwell, Louise O'Keefe, Stephanie Schwartz, Dalit Vaizel-Ohayon, Eyal Schejter, Andrew Tomlinson, Stephen DiNardo, arrow encodes an LDL-receptor-related protein essential for Wingless signalling Nature. ,vol. 407, pp. 527- 530 ,(2000) , 10.1038/35035110
Maurice M. Rapport, Arda.Alden. Green, Irvine H. Page, SERUM VASOCONSTRICTOR (SEROTONIN) IV. ISOLATION AND CHARACTERIZATION Journal of Biological Chemistry. ,vol. 176, pp. 1243- 1251 ,(1948) , 10.1016/S0021-9258(18)57137-4
Betty M. Twarog, Irvine H. Page, Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its Determination American Journal of Physiology. ,vol. 175, pp. 157- 161 ,(1953) , 10.1152/AJPLEGACY.1953.175.1.157
Keiko Tamai, Mikhail Semenov, Yoichi Kato, Rebecca Spokony, Chunming Liu, Yu Katsuyama, Fred Hess, Jean-Pierre Saint-Jeannet, Xi He, LDL-receptor-related proteins in Wnt signal transduction Nature. ,vol. 407, pp. 530- 535 ,(2000) , 10.1038/35035117
PR Wade, J Chen, B Jaffe, IS Kassem, RD Blakely, MD Gershon, Localization and Function of a 5-HT Transporter in Crypt Epithelia of the Gastrointestinal Tract The Journal of Neuroscience. ,vol. 16, pp. 2352- 2364 ,(1996) , 10.1523/JNEUROSCI.16-07-02352.1996
Vijay K. Yadav, Patricia Ducy, Lrp5 and bone formation Annals of the New York Academy of Sciences. ,vol. 1192, pp. 103- 109 ,(2010) , 10.1111/J.1749-6632.2009.05312.X
Desnos C, Massoulie J, Isambert Mf, Raisman-Vozari R, Botton D, Henry Jp, Krejci E, Gasnier B, Sagne C, Blanchard, Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules. The Journal of Experimental Biology. ,vol. 196, pp. 251- 262 ,(1994) , 10.1242/JEB.196.1.251
W. Lovenberg, E. Jequier, A. Sjoerdsma, Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor Science. ,vol. 155, pp. 217- 219 ,(1967) , 10.1126/SCIENCE.155.3759.217
RAY W. FULLER, DAVID T. WONG, Serotonin uptake and serotonin uptake inhibition. Annals of the New York Academy of Sciences. ,vol. 600, pp. 68- 80 ,(1990) , 10.1111/J.1749-6632.1990.TB16873.X
Diego J Walther, Jens-Uwe Peter, Sandra Winter, Markus Höltje, Nils Paulmann, Maik Grohmann, Jakob Vowinckel, Victor Alamo-Bethencourt, Claudia S Wilhelm, Gudrun Ahnert-Hilger, Michael Bader, Serotonylation of small GTPases is a signal transduction pathway that triggers platelet α-granule release Cell. ,vol. 115, pp. 851- 862 ,(2003) , 10.1016/S0092-8674(03)01014-6