作者: Patricia Ducy
DOI: 10.1016/B978-0-12-415784-2.00007-5
关键词: Bone remodeling 、 Osteoporosis 、 Serotonin Production 、 Anabolism 、 Tryptophan hydroxylase 、 Internal medicine 、 Serotonin 、 Biology 、 Endocrinology 、 Osteoblast 、 Phenotype
摘要: Adding to the ever-growing list of molecules involved in regulating bone remodeling, gut-derived serotonin was recently shown specifically control formation side this process. Indeed, mice deficient tryptophan hydroxylase 1, rate-limiting enzyme controlling production by gut cells, have a high mass phenotype caused solely increased osteoblast proliferation. Furthermore, when treated with inhibitor able decrease synthesis, and rats display an increase that is sufficient counterbalance loss induced ovariectomy long bones as well vertebrae. Importantly, low levels circulating also been correlated with, respectively, decreased humans. These findings raise prospect pharmacologically manipulating could become novel strategy treat disorders such osteoporosis through anabolic approach.