The Amoroso Lecture. The human spermatozoon--a cell in crisis?

摘要: A great deal of evidence has accumulated in recent years to suggest that there been a gradual increase male reproductive pathology over the past 30-40 years, as evidenced by increased rates testicular cancer and declining semen quality. The hypothesis is advanced this phenomenon causally related ability germ cells generate reactive oxygen metabolites. When produced low levels, such metabolites are thought enhance sperm function stimulating DNA compaction promoting redox-regulated cAMP-mediated pathway central induction capacitation. excessive amounts, same stimulate fragmentation loss associated with peroxidative damage plasma membrane. Free radical-induced mutations line may also be involved aetiology childhood increases incidence seminoma. In light these considerations, establishing mechanisms for free radical generation determining factors influence activity important objectives future research area.