Differential shared genetic influences on anxiety with problematic alcohol use compared to alcohol consumption.
作者： Sarah Mary Carlton Colbert , Scott A Funkhouser , Emma C Johnson , Charles A Hoeffer , Marissa A Ehringer
DOI: 10.1101/2020.08.21.20179374
关键词: Anxiety 、 Genetic correlation 、 Regression 、 Alcohol 、 Linkage disequilibrium 、 Clinical psychology 、 Comorbidity 、 Psychology 、 Amygdala 、 Alcohol consumption
摘要: Abstract Anxiety disorders and alcohol use are common psychiatric illnesses. Comorbidity of the two can have a tremendous effect on treatment one or both disorders, as well an individual’s social, economic, physical well-being. We estimated genome-wide genetic correlations between anxiety traits using linkage disequilibrium score regression (LDSC) found strong positive with problematic (PAU), but not most consumption (AC) measures. observed strong, between-sex for all traits, suggestive evidence that correlation might differ males females. Estimates local covariance demonstrated divergent profiles PAU AC phenotypes localized 12 specific genomic regions likely contribute to use. Finally, partitioning among functional annotations also identified amygdala, caudate basal ganglia frontal cortex contributing significantly phenotypes. This study serves framework approach be used in future analyses genetics comorbid disorders.
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