NMR and chiroptical examination of the diastereoisomers of (S)-Eu–EOB–DTPA
作者： Nicola C. Thompson , David Parker , Heribert Schmitt-Willich , Detlev Sülzle , Gilles Muller
DOI: 10.1039/B403863K
关键词: Crystallography 、 Carbon-13 NMR satellite 、 Emission spectrum 、 Absolute configuration 、 Bound water 、 Luminescence 、 Proton NMR 、 Spectroscopy 、 Chemistry 、 Stereochemistry 、 Diastereomer
摘要: The solution structure of the diastereoisomers (S)-Eu–EOB–DTPA has been analysed by 1H NMR, CD and CPL spectroscopy. Two major species exist which possess very similar NMR paramagnetic shifts emission spectra, consistent with a 9-coordinate involving one bound water. Circularly polarised luminescence data are common Λ-helicity for each isomer; isomers differ only in absolute configuration central nitrogen atom.
rsc.org
sci-hub.se 参考文章(18)
James P. Riehl, Frederick S. Richardson, Circularly polarized luminescence. Methods in Enzymology. ,vol. 226, pp. 539- 553 ,(1993) , 10.1016/0076-6879(93)26024-4
Andrew Beeby, Ian M. Clarkson, Rachel S. Dickins, Stephen Faulkner, David Parker, Louise Royle, Alvaro S. de Sousa, J. A. Gareth Williams, Mark Woods, Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states Journal of The Chemical Society-perkin Transactions 1. pp. 493- 504 ,(1999) , 10.1039/A808692C
Gabriella Bobba, Rachel S. Dickins, Suzanna D. Kean, Céline E. Mathieu, David Parker, Robert D. Peacock, Giuliano Siligardi, Martin J. Smith, J. A. Gareth Williams, Carlos F. G. C. Geraldes, Chiroptical, ESMS and NMR spectroscopic study of the interaction of enantiopure lanthanide complexes with selected self-complementary dodecamer oligonucleotides Journal of The Chemical Society-perkin Transactions 1. pp. 1729- 1737 ,(2001) , 10.1039/B104796P
Randall B. Lauffer, Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design Chemical Reviews. ,vol. 87, pp. 901- 927 ,(1987) , 10.1021/CR00081A003
Linda J. Govenlock, Judith A. K. Howard, Janet M. Moloney, David Parker, Robert D. Peacock, Giuliano Siligardi, CHIROPTICAL FEATURES AND LUMINESCENCE BEHAVIOUR OF MACROCYCLIC TETRA(4-QUINOLYL)-COMPLEXES : SURPRISING ABSENCE OF EXCITON COUPLING Journal of The Chemical Society-perkin Transactions 1. pp. 2415- 2418 ,(1999) , 10.1039/A905512F
Peter Caravan, Jeffrey J. Ellison, Thomas J. McMurry, Randall B. Lauffer, Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications Chemical Reviews. ,vol. 99, pp. 2293- 2352 ,(1999) , 10.1021/CR980440X
Silvio Aime, Mauro Botta, Giuseppe Ermondi, NMR study of solution structures and dynamics of lanthanide(III) complexes of DOTA Inorganic Chemistry. ,vol. 31, pp. 4291- 4299 ,(1992) , 10.1021/IC00047A016
Rachel S. Dickins, Judith A. K. Howard, Christine L. Maupin, Janet M. Moloney, David Parker, James P. Riehl, Giuliano Siligardi, J. A. Gareth Williams, Synthesis, Time-Resolved Luminescence, NMR Spectroscopy, Circular Dichroism and Circularly Polarised Luminescence Studies of Enantiopure Macrocyclic Lanthanide Tetraamide Complexes Chemistry - A European Journal. ,vol. 5, pp. 1095- 1105 ,(1999) , 10.1002/(SICI)1521-3765(19990301)5:3<1095::AID-CHEM1095>3.0.CO;2-C
Silvio Aime, Alessandro Barge, James I. Bruce, Mauro Botta, Judith A. K. Howard, Janet M. Moloney, David Parker, Alvaro S. de Sousa, Mark Woods, NMR, Relaxometric, and Structural Studies of the Hydration and Exchange Dynamics of Cationic Lanthanide Complexes of Macrocyclic Tetraamide Ligands Journal of the American Chemical Society. ,vol. 121, pp. 5762- 5771 ,(1999) , 10.1021/JA990225D
P Reimer, E J Rummeny, K Shamsi, T Balzer, H E Daldrup, B Tombach, T Hesse, T Berns, P E Peters, Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology. ,vol. 199, pp. 177- 183 ,(1996) , 10.1148/RADIOLOGY.199.1.8633143