The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
作者： Lars Porskjær Christensen , Kathrine Bisgaard Christensen
DOI: 10.1016/B978-0-12-398456-2.00023-2
关键词: Cysteine 、 Antioxidant 、 KEAP1 、 Polyphenol 、 Cytosol 、 Chemistry 、 Reactive oxygen species 、 Oxidative stress 、 Biochemistry 、 Glutathione
摘要: A series of exogenous compounds are able to protect against oxidative stress by induction phase 2 enzymes (cytoprotective proteins) through activation the redox sensitive Keap1-Nrf2-ARE regulatory pathway. Inducers cytoprotective proteins are, for example, found among polyphenols which many present in our daily diet. Polyphenol inducers either Michael acceptors or can be metabolized reactive electrophiles capable alkylating cysteine thiols Keap1 and/or induce formation cytosolic oxygen species resulting release Nrf2 followed gene transcription ARE leading proteins. Polyphenols direct antioxidants vitro, but nevertheless seem exert their antioxidant effect more that involved a variety actions from reduction oxidants production endogenous (e.g., glutathione). Therefore protection vivo is mainly due indirect effect.
elsevier.com
sci-hub.se 参考文章(192)
Margaret E. Wright, Susan T. Mayne, Christine A. Swanson, Rashmi Sinha, Michael C.R. Alavanja, Dietary carotenoids, vegetables, and lung cancer risk in women: the Missouri women's health study (United States). Cancer Causes & Control. ,vol. 14, pp. 85- 96 ,(2003) , 10.1023/A:1022565601937
A Meister, Glutathione metabolism and its selective modification. Journal of Biological Chemistry. ,vol. 263, pp. 17205- 17208 ,(1988) , 10.1016/S0021-9258(19)77815-6
W B Jakoby, D M Ziegler, THE ENZYMES OF DETOXICATION Journal of Biological Chemistry. ,vol. 265, pp. 20715- 20718 ,(1990) , 10.1016/S0021-9258(17)45272-0
K. Sahin, C. Orhan, F. Akdemir, M. Tuzcu, C. Iben, N. Sahin, Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins Journal of Animal Physiology and Animal Nutrition. ,vol. 96, pp. 66- 74 ,(2012) , 10.1111/J.1439-0396.2010.01123.X
A Spector, G Z Yan, R R Huang, M J McDermott, P R Gascoyne, V Pigiet, The effect of H2O2 upon thioredoxin-enriched lens epithelial cells. Journal of Biological Chemistry. ,vol. 263, pp. 4984- 4990 ,(1988) , 10.1016/S0021-9258(18)68884-2
K Brandt, L.P Christensen, J Hansen-Møller, S.L Hansen, J Haraldsdottir, L Jespersen, S Purup, A Kharazmi, V Barkholt, H Frøkiær, M Kobæk-Larsen, Health promoting compounds in vegetables and fruits: A systematic approach for identifying plant components with impact on human health Trends in Food Science and Technology. ,vol. 15, pp. 384- 393 ,(2004) , 10.1016/J.TIFS.2003.12.003
W R Pearson, J J Windle, J F Morrow, A M Benson, P Talalay, Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA. Journal of Biological Chemistry. ,vol. 258, pp. 2052- 2062 ,(1983) , 10.1016/S0021-9258(18)33096-5
H Z Chae, S J Chung, S G Rhee, Thioredoxin-dependent peroxide reductase from yeast. Journal of Biological Chemistry. ,vol. 269, pp. 27670- 27678 ,(1994) , 10.1016/S0021-9258(18)47038-X
Barry Halliwell, John M.C. Gutteridge, Role of free radicals and catalytic metal ions in human disease: an overview. Methods in Enzymology. ,vol. 186, pp. 1- 85 ,(1990) , 10.1016/0076-6879(90)86093-B
Dominique S Michaud, Diane Feskanich, Eric B Rimm, Graham A Colditz, Frank E Speizer, Walter C Willett, Edward Giovannucci, Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. The American Journal of Clinical Nutrition. ,vol. 72, pp. 990- 997 ,(2000) , 10.1093/AJCN/72.4.990