The DNA Provirus: Howard Temin's Scientific Legacy

摘要: Part I: Selected papers of Howard M Temin Reprint and Rubin's 1958 paper describing the focus assay for transformation by Rous Sarcoma virus Temin's 1964 proposing DNA provirus hypothesis Boettiger 1970 on inactivation BUdR-containing proviral visible light Mizutani's reporting discovery reverse transcriptase 1971 protovirus II: Cancer On origin oncogenes Viruses, genes cancer: a lineage Mammaliam development human from phage group to genetics intestinal cancer Malignant cells v-Rel oncoprotein Progress in molecular medicine III: Virology Shimotohno, Mizutani 1980 similarity structure retroviral proviruses that transposable elements Beyond provirus: insights study Eppstein-Barr virus, prototypic tumor Under influence: multistep carcinogenesis Herpes simplex replication genome maturation 1993 inherent contributions transcription variation Retrovirus evolution IV: HIV, AIDS immune system Human retroviruses second decade: some pathogenic mechanisms approaches their control Cherish an idea does not attach itself anything Gene therapy CD4+ T lymphocytes SCID-hu mice The dilemma developing testing vaccines reprint temin's new approach develop immunodeficiency vaccine