Chimeric LuxR Transcription Factors Rewire Natural Product Regulation
作者： Ruchira Mukherji , Shuaibing Zhang , Somak Chowdhury , Pierre Stallforth
DOI: 10.1101/584987
关键词: Cell biology 、 Transcriptional Activator 、 Gene 、 Transcription factor 、 Biology 、 Natural product
摘要: … biosynthetic gene clusters. Novel approaches to activate these silent gene clusters thus greatly … bacterial biosynthetic gene clusters (BGCs) can be altered in order to modulate and even …
sci-hub.st 参考文章(13)
Sujatha Subramoni, Vittorio Venturi, LuxR-family 'solos': bachelor sensors/regulators of signalling molecules Microbiology. ,vol. 155, pp. 1377- 1385 ,(2009) , 10.1099/MIC.0.026849-0
David J. Newman, Gordon M. Cragg, Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 Journal of Natural Products. ,vol. 75, pp. 311- 335 ,(2012) , 10.1021/NP200906S
Robert M. Q. Shanks, Nicky C. Caiazza, Shannon M. Hinsa, Christine M. Toutain, George A. O'Toole, Saccharomyces cerevisiae-Based Molecular Tool Kit for Manipulation of Genes from Gram-Negative Bacteria Applied and Environmental Microbiology. ,vol. 72, pp. 5027- 5036 ,(2006) , 10.1128/AEM.00682-06
Jaclyn M Winter, Swantje Behnken, Christian Hertweck, Genomics-inspired discovery of natural products Current Opinion in Chemical Biology. ,vol. 15, pp. 22- 31 ,(2011) , 10.1016/J.CBPA.2010.10.020
Frank Uliczka, Fabio Pisano, Annika Kochut, Wiebke Opitz, Katharina Herbst, Tatjana Stolz, Petra Dersch, Monitoring of Gene Expression in Bacteria during Infections Using an Adaptable Set of Bioluminescent, Fluorescent and Colorigenic Fusion Vectors PLoS ONE. ,vol. 6, pp. e20425- ,(2011) , 10.1371/JOURNAL.PONE.0020425
Kim Lewis, Platforms for antibiotic discovery Nature Reviews Drug Discovery. ,vol. 12, pp. 371- 387 ,(2013) , 10.1038/NRD3975
Mair E. A. Churchill, Lingling Chen, Structural basis of acyl-homoserine lactone-dependent signaling. Chemical Reviews. ,vol. 111, pp. 68- 85 ,(2011) , 10.1021/CR1000817
Harald Gross, Joyce E. Loper, Genomics of secondary metabolite production by Pseudomonas spp. Natural Product Reports. ,vol. 26, pp. 1408- 1446 ,(2009) , 10.1039/B817075B
Marvin Whiteley, E. P. Greenberg, Promoter Specificity Elements in Pseudomonas aeruginosa Quorum-Sensing-Controlled Genes Journal of Bacteriology. ,vol. 183, pp. 5529- 5534 ,(2001) , 10.1128/JB.183.19.5529-5534.2001
David J. Newman, Gordon M. Cragg, Kenneth M. Snader, The influence of natural products upon drugdiscovery Natural Product Reports. ,vol. 17, pp. 215- 234 ,(2000) , 10.1039/A902202C