Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients

摘要: Glioblastoma is the most common malignant primary brain tumor. Despite recent advances, overall prognosis remains poor with median survivals of approximately 1 year and 5-year less than 5%. Efforts at risk stratification have identified age performance status as important prognostic features. It well established that patients treated postoperative radiation therapy improved survival functional capacity compared unirradiated patients. Recent evidence suggests benefit persists even within cohort aged 70 years or over. Some investigators questioned whether standard treatment schedule 60 Gy delivered over a 6-week period necessary for older limited status. Alternative schedules been devised to reduce inconvenience morbidity therapy. This review aims evaluate current state knowledge on alternative radiotherapy elderly poor-prognosis glioblastoma.