Effect of sertraline on proliferation and neurogenic differentiation of human adipose-derived stem cells
作者： Shahnaz Razavi , Maliheh Jahromi , Nushin Amirpour , Zahra Khosravizadeh
关键词: Sertraline 、 Adult stem cell 、 Stem cell 、 Autologous transplantation 、 Medicine 、 Adipose tissue 、 Pharmacology 、 MTT assay 、 Gliogenesis 、 Antidepressant
摘要: Background: Antidepressant drugs are commonly employed for anxiety and mood disorders. Sertraline is extensively used as antidepressant in clinic. In addition, adipose tissue represents an abundant accessible source of adult stem cells with the ability to differentiate multiple lineages. Therefore, human adipose-derived (hADSCs) may be useful autologous transplantation. Materials Methods: present study, we assessed effect drug on proliferation neurogenic differentiation hADSCs using MTT assay immunofluorescence technique respectively. Results: analysis showed that 0.5 μM significantly increased rate induced (P Conclusion: Overall, our data show can promoting during after 6 days post-induction, while inhibits gliogenesis hADSCs.
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advbiores.net参考文章(50)
Vincenzo Vindigni, Barbara Zavan, Roberta Cortivo, Giovanni Abatangelo, Alessandro Della Puppa, Chiara Gardin, Domenico D'Avella, Neural potential of adipose stem cells. Discovery Medicine. ,vol. 10, pp. 37- 43 ,(2010)
Brian Johnstone, Thomas M. Hering, Arnold I. Caplan, Victor M. Goldberg, Jung U. Yoo, In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells Experimental Cell Research. ,vol. 238, pp. 265- 272 ,(1998) , 10.1006/EXCR.1997.3858
Linli Shi, Xiangqun Yang, None, Differentiation potential and application of stem cells from adipose tissue Chinese Journal of Reparative and Reconstructive Surgery. ,vol. 26, pp. 1007- ,(2012)
Scott P. Bruder, Neelam Jaiswal, Nancy S. Ricalton, Joseph D. Mosca, Karl H. Kraus, Sudha Kadiyala, Mesenchymal stem cells in osteobiology and applied bone regeneration. Clinical Orthopaedics and Related Research. ,vol. 355, pp. 247- 256 ,(1998) , 10.1097/00003086-199810001-00025
Juri Fujimura, Rei Ogawa, Hiroshi Mizuno, Yoshitaka Fukunaga, Hidenori Suzuki, None, Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. Biochemical and Biophysical Research Communications. ,vol. 333, pp. 116- 121 ,(2005) , 10.1016/J.BBRC.2005.05.096
Hari Manev, Tolga Uz, Neil R Smalheiser, Radmila Manev, Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro European Journal of Pharmacology. ,vol. 411, pp. 67- 70 ,(2001) , 10.1016/S0014-2999(00)00904-3
Patrick Schloss, Fritz A. Henn, New insights into the mechanisms of antidepressant therapy. Pharmacology & Therapeutics. ,vol. 102, pp. 47- 60 ,(2004) , 10.1016/J.PHARMTHERA.2004.02.001
Patrick C McHugh, Geraldine R Rogers, Barbara Loudon, Dylan M Glubb, Peter R Joyce, Martin A Kennedy, None, Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine Journal of Neuroscience Research. ,vol. 86, pp. 306- 316 ,(2008) , 10.1002/JNR.21482
Shinji Kusakawa, Kazuaki Nakamura, Yuki Miyamoto, Atsushi Sanbe, Tomohiro Torii, Junji Yamauchi, Akito Tanoue, Fluoxetine promotes gliogenesis during neural differentiation in mouse embryonic stem cells Journal of Neuroscience Research. ,vol. 88, pp. 3479- 3487 ,(2010) , 10.1002/JNR.22509
Levent Sutcigil, Cagatay Oktenli, Ugur Musabak, Ali Bozkurt, Adnan Cansever, Ozcan Uzun, S. Yavuz Sanisoglu, Zeki Yesilova, Nahit Ozmenler, Aytekin Ozsahin, Ali Sengul, Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy. Clinical & Developmental Immunology. ,vol. 2007, pp. 76396- 76396 ,(2007) , 10.1155/2007/76396