In vitro changes in mitochondrial potential, aggresome formation and caspase activity by a novel 17-β-estradiol analogue in breast adenocarcinoma cells.

作者: Danielle S Nkandeu , Thandi V Mqoco , Michelle H Visagie , Barend A Stander , Elize Wolmarans

DOI: 10.1002/CBF.2937

关键词: MCF-7Caspase activityAggresomeCancer research17 β estradiolMedicineIn vitroBreast AdenocarcinomaCancer2-MethoxyestradiolImmunology

摘要: The Medical Research Council of South Africa (AK076; AL343), the Cancer Association (AK246), RESCOM, School Medicine (Faculty Health Sciences, University Pretoria), National Foundation (AL239) and Struwig-Germeshuysen Trust (AN074). Bioinformatics Computational Biology Unit (University Pretoria) contributed to in silico-design compound.

参考文章(33)
D. Ross Camidge, Qing Zhou, Daniel Gustafson, Sujatha Nallapareddy, Sami Diab, Stephen Leong, Karl Lewis, Lia Gore, Wells A. Messersmith, Anthony M. Treston, S. Gail Eckhardt, Carolyn Sidor, A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer. Investigational New Drugs. ,vol. 29, pp. 340- 346 ,(2011) , 10.1007/S10637-009-9383-9
Gregory E. Agoston, Jamshed H. Shah, Lita Suwandi, Arthur D. Hanson, Xiaoguo Zhan, Theresa M. LaVallee, Victor Pribluda, Anthony M. Treston, Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol Bioorganic & Medicinal Chemistry Letters. ,vol. 19, pp. 6241- 6244 ,(2009) , 10.1016/J.BMCL.2009.08.020
Su Jin Kang, Byeong Mo Kim, Young Joon Lee, Sung Hee Hong, Hai Won Chung, Titanium dioxide nanoparticles induce apoptosis through the JNK/p38-caspase-8-Bid pathway in phytohemagglutinin-stimulated human lymphocytes. Biochemical and Biophysical Research Communications. ,vol. 386, pp. 682- 687 ,(2009) , 10.1016/J.BBRC.2009.06.097
M. Narita, S. Shimizu, T. Ito, T. Chittenden, R. J. Lutz, H. Matsuda, Y. Tsujimoto, Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 14681- 14686 ,(1998) , 10.1073/PNAS.95.25.14681
Zhaoyu Jin, Yun Li, Robert Pitti, David Lawrence, Victoria C. Pham, Jennie R. Lill, Avi Ashkenazi, Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling Cell. ,vol. 137, pp. 721- 735 ,(2009) , 10.1016/J.CELL.2009.03.015
Wilfried Bursch, Anneliese Karwan, Miriam Mayer, Julia Dornetshuber, Ulrike Fröhwein, Rolf Schulte-Hermann, Barbara Fazi, Federica Di Sano, Lucia Piredda, Mauro Piacentini, Goran Petrovski, László Fésüs, Christopher Gerner, Cell death and autophagy: cytokines, drugs, and nutritional factors. Toxicology. ,vol. 254, pp. 147- 157 ,(2008) , 10.1016/J.TOX.2008.07.048
G Basanez, A Nechushtan, O Drozhinin, A Chanturiya, E Choe, S Tutt, KA Wood, Y-T Hsu, J Zimmerberg, RJ Youle, None, Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 5492- 5497 ,(1999) , 10.1073/PNAS.96.10.5492
Barbara S. Hulka, Patricia G. Moorman, Breast cancer: hormones and other risk factors. Maturitas. ,vol. 38, pp. 103- 113 ,(2001) , 10.1016/S0378-5122(00)00196-1
Y Kondo, S Kondo, T Kanzawa, I M Germano, T Komata, H Ito, Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells Cell Death & Differentiation. ,vol. 11, pp. 448- 457 ,(2004) , 10.1038/SJ.CDD.4401359