Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model.
作者： Malin E. V. Johansson , Jenny K. Gustafsson , Karolina E. Sjöberg , Joel Petersson , Lena Holm
DOI: 10.1371/JOURNAL.PONE.0012238
关键词: Colitis 、 Chemistry 、 Mucus 、 Mucin 、 Intestinal mucosa 、 Bacteria 、 Dextran 、 Microbiology 、 Large intestine 、 Inner mucus layer
摘要: Background: Protection of the large intestine with its enormous amount commensal bacteria is a challenge that became easier to understand when we recently could describe colon has an inner ...
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Kazuko Shichijo, Mutsumi Matuu, Yuji Ikeda, Shinji Naito, Masahiro Ito, Ichiro Sekine, Clinicopathologic study of dextran sulfate sodium experimental murine colitis Laboratory Investigation. ,vol. 69, pp. 238- 249 ,(1998) , 10.1016/S0021-5198(19)41298-5
Isao Okayasu, Shigeru Hatakeyama, Masahiro Yamada, Toshifumi Ohkusa, Yoshio Inagaki, Rintaro Nakaya, A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology. ,vol. 98, pp. 694- 702 ,(1990) , 10.1016/0016-5085(90)90290-H
Emily K. K. Tai, C. H. Cho, Helen P. S. Wong, William K. K. Wu, L. Yu, Emily K. Y. Lam, A new role for cathelicidin in ulcerative colitis in mice. Experimental Biology and Medicine. ,vol. 232, pp. 799- 808 ,(2007) , 10.3181/00379727-232-2320799
Michael Mähler, Ian J. Bristol, Edward H. Leiter, Aletha E. Workman, Edward H. Birkenmeier, Charles O. Elson, John P. Sundberg, Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 274, ,(1998) , 10.1152/AJPGI.1998.274.3.G544
Maria Van der Sluis, Barbara A.E. De Koning, Adrianus C.J.M. De Bruijn, Anna Velcich, Jules P.P. Meijerink, Johannes B. Van Goudoever, Hans A. Büller, Jan Dekker, Isabelle Van Seuningen, Ingrid B. Renes, Alexandra W.C. Einerhand, Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection Gastroenterology. ,vol. 131, pp. 117- 129 ,(2006) , 10.1053/J.GASTRO.2006.04.020
Shuji KITAJIMA, Masatoshi MORIMOTO, Eiji SAGARA, Chiharu SHIMIZU, Yoshifumi IKEDA, Dextran Sodium Sulfate-Induced Colitis in Germ-Free IQI/Jic Mice Experimental Animals. ,vol. 50, pp. 387- 395 ,(2001) , 10.1538/EXPANIM.50.387
Gunnar C. Hansson, Malin E.V. Johansson, The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut microbes. ,vol. 1, pp. 51- 54 ,(2010) , 10.4161/GMIC.1.1.10470
Malin E. V. Johansson, Kristina A. Thomsson, Gunnar C. Hansson, Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. Journal of Proteome Research. ,vol. 8, pp. 3549- 3557 ,(2009) , 10.1021/PR9002504
Yutao Yan, Vasantha Kolachala, Guillaume Dalmasso, Hang Nguyen, Hamed Laroui, Shanthi V. Sitaraman, Didier Merlin, Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis PLoS ONE. ,vol. 4, pp. e6073- ,(2009) , 10.1371/JOURNAL.PONE.0006073
Mia Johansson, Ingrid Synnerstad, Lena Holm, None, Acid Transport Through Channels in the Mucous Layer of Rat Stomach Gastroenterology. ,vol. 119, pp. 1297- 1304 ,(2000) , 10.1053/GAST.2000.19455