Atypical developmental features of cortical thickness trajectories in Autism Spectrum Disorder

摘要: Abstract Neuroimaging studies have reported numerous region-specific atypicalities in the brains of individuals with Autism Spectrum Disorder (ASD), including alterations cortical thickness (CT). However, there are many inconsistent findings, and this is probably due to atypical CT developmental trajectories ASD. To end, we investigated group differences terms shapes between ASD typically developing (TD) populations. Using Brain Imaging Data Exchange (ABIDE) repository (releases I II combined), using a linear, quadratic cubic models at various scales spatial coarseness, their association symptomatology Diagnostic Observation Schedule (ADOS) scores. These parameters were also used predict TD development. While no overall was observed across entire age range, populations different age-related changes. Developmental mostly characterized by decreased thinning during early adolescence increased later stages, involving frontal parietal areas. Such changes associated ADOS The curvature estimated from model most accurate sensitive measure for detecting Our findings suggest that under context longitudinal brain morphology, robust detection would require three time points estimate