The Nobel Lectures in Immunology. Lecture for the Nobel Prize for Physiology or Medicine, 1980: Studies in histocompatibility.

摘要: As George Snell [1] so rightly said, the supergene, major histocompatibility complex (MHC), is like a page from nature book read outside of context. Today this context beginning to be better understood. We would here torecall evolution concepts regarding these molecular structures found in membrane cells. First, attention was centred on almost botanical description their genetic polymorphism. Then spotlight turned, for several years, importance transplantation. More recently, role immune response has become more and apparent