Physiology and pathophysiology of myelinated nerve fibers.

摘要: The chief role of the axon is that impulse conduction, which depends on electrical cable structure and voltage-dependent ion channels axonal membrane. Over recent decades, development specialized techniques such as patch clamping site-directed mutagenesis have established contribution neuronal channel function to processes conduction in myelinated nerves. Recently, these insights from vitro studies been translated into clinical realm. In keeping with this progress, excitability developed provide information related activity a variety channels, energy-dependent pumps, exchange activated during peripheral axons. These noninvasive extensively applied study biophysical properties human nerves vivo provided important health neurological disease, particularly relation pathophysiological mechanisms underlie neuropathy.