Evaluation of mitoxantrone for the treatment of lymphoma in dogs

摘要: Mitoxantrone was administered to 74 dogs with lymphoma at a dosage of 5.0 mg/m2 body surface, IV, every 3 weeks. Thirty-four had failed respond prior treatment chemotherapeutic agents, which included doxorubicin (33 dogs). The remaining 40 not received treatment. Complete remission determined in 19 (26%), 10 median duration for these 94 days (range, 49 440 days, 2 still alive 370 and respectively). Nine that complete lasted 126 42 792 1 dog days). combined rate (complete plus partial remission) 41%. Toxicosis minimal, developing only 9 requiring hospitalization dogs. We concluded the ascertained when mitoxantrone low, compared treatments involved other agents; however, 41% indicated may be beneficial