From Lipid Transport to Oxygenation of Aromatic Compounds: Evolution within the Bet v1-like Superfamily

作者: Joydeep Chakraborty , Tapan K. Dutta

DOI: 10.1080/07391102.2011.10507375

关键词: SUPERFAMILYLipid TransportProtein subunitPhylogenetic relationshipRieske proteinProtein superfamilyEvolutionary biologyBiologyHomology (biology)BiochemistryStructural alignment

摘要: Abstract In absence of significant sequence similarity, remote homology between proteins can be confused with analogy and in such a case, shared ancestry inferred light certain unique common features. the present study, to understand evolutionary origin catalytic domain large subunit ring-hydroxylating oxygenases (RHOs), belonging Bet v1-like superfamily, structure-based phylogenies have been derived from structural alignment representative superfamily. A careful inspection relatedness RHOs rest families showed closest similarity RHO PA1206-like protein. addition, phylogenetic relationship Rieske functionally structurally similar has also elucidated so as postulate most possible events leading genesis RHOs.

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