Physical Studies on the Interaction of Lysergic Acid Diethylamide and Trypanocidal Dyes with DNA and DNA-Containing Genetic Material
作者： Thomas E. Wagner
DOI: 10.1007/978-3-642-65141-0_14
关键词: Chromatid 、 DNA 、 Lysergic acid diethylamide 、 In vitro 、 Lysergic acid 、 Ethidium bromide 、 Chromosome 、 Biochemistry 、 Dicentric chromosome 、 Chemistry
摘要: Both lysergic acid diethylamide (LSD-25) and the trypanocidal dyes ethidium bromide isometamidium methanesulfonate have been shown to affect genetic structures. The induction of chromosomal damage in peripheral lymphocytes by derivative LSD-25 has clearly demonstrated both vitro vivo experiments (Cohen, 1969). majority abnormalities apparently induced are simple chromatid isochromatid breaks, although several exchanges dicentric chromosomes observed (Irvin Egozcue, 1967; Cohen, Morinello Back, 1967). observation a specific interaction between DNA (Wagner, 1969; Yielding Sternglanz, 1968; Smythies Antun, 1969) suggests that may function material interacting directly with component chromosome.
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