The comparative biology of neuromelanin and lipofuscin in the human brain
作者： K. L. Double , V. N. Dedov , H. Fedorow , E. Kettle , G. M. Halliday
DOI: 10.1007/S00018-008-7581-9
关键词: Neuromelanin 、 Function (biology) 、 Lipofuscin 、 Cell aging 、 Lipofuscin accumulation 、 Neuroscience 、 Human brain 、 Pathology 、 Comparative biology 、 Aging brain 、 Biology
摘要: Neuromelanin and lipofuscin are two pigments produced within the human brain that, until recently, were considered inert cellular waste products of little interest to neuroscience. Recent research has increased our understanding nature interactions these with their environment suggests that may, indeed, influence function. The physical appearance distribution differ, but both accumulate in aging share some structural features. Lipofuscin accumulation been implicated postmitotic cell aging, while neuromelanin is suggested function as an iron-regulatory molecule possible protective functions cells which produce this pigment. This review presents comparative aspects biology lipofuscin, well a discussion hypothesized roles neurodegenerative disease.
springer.com
core.ac.uk
sci-hub.se 参考文章(95)
K. L. Double, G. M. Halliday, New face of neuromelanin Parkinson’s Disease and Related Disorders. pp. 119- 123 ,(2006) , 10.1007/978-3-211-45295-0_19
P.G. Guyenet, Central noradrenergic neurons: the autonomic connection. Progress in Brain Research. ,vol. 88, pp. 365- 380 ,(1991) , 10.1016/S0079-6123(08)63823-6
Ulrich Schraermeyer, Peter Kayatz, Gabriele Thumann, Thomas T. Luther, Peter J. Esser, Jens F. Jordan, Karl Ulrich Bartz-Schmidt, Oxidation causes melanin fluorescence. Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 241- 246 ,(2001)
F. Tribl, T. Arzberger, P. Riederer, M. Gerlach, Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis. Journal of Neural Transmission-supplement. pp. 51- 55 ,(2007) , 10.1007/978-3-211-73574-9_8
Eva Braak, Daniele Sandmann-Keil, Udo Rüb, Wei Ping Gai, Rob A. I. de Vos, Ernst N. H. Jansen Steur, Kimihito Arai, Heiko Braak, alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei. Acta Neuropathologica. ,vol. 101, pp. 195- 201 ,(2001) , 10.1007/S004010000247
Ashley Reynolds, Chad Laurie, R. Lee Mosley, Howard E. Gendelman, Oxidative stress and the pathogenesis of neurodegenerative disorders. International Review of Neurobiology. ,vol. 82, pp. 297- 325 ,(2007) , 10.1016/S0074-7742(07)82016-2
Ulf T Brunk, Alexei Terman, Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. Free Radical Biology and Medicine. ,vol. 33, pp. 611- 619 ,(2002) , 10.1016/S0891-5849(02)00959-0
Kazumasa Wakamatsu, Kenichi Fujikawa, Fabio A. Zucca, Luigi Zecca, Shosuke Ito, The structure of neuromelanin as studied by chemical degradative methods. Journal of Neurochemistry. ,vol. 86, pp. 1015- 1023 ,(2003) , 10.1046/J.1471-4159.2003.01917.X
Milan Elleder, Jan Borovanský, Autofluorescence of melanins induced by ultraviolet radiation and near ultraviolet light. A histochemical and biochemical study. Histochemical Journal. ,vol. 33, pp. 273- 281 ,(2001) , 10.1023/A:1017925023408
Mauro Fasano, Sabrina Giraudo, Silvia Coha, Bruno Bergamasco, Leonardo Lopiano, None, Residual substantia nigra neuromelanin in Parkinson’s disease is cross-linked to α-synuclein Neurochemistry International. ,vol. 42, pp. 603- 606 ,(2003) , 10.1016/S0197-0186(02)00161-4