Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats.
作者： Thangarasu Rajakumar , Pachaiappan Pugalendhi , Subbaiyan Thilagavathi
DOI: 10.1016/J.CBI.2015.02.015
关键词: DMBA 、 Biochemistry 、 7,12-Dimethylbenz[a]anthracene 、 Lipoprotein 、 Endocrinology 、 Mammary gland 、 Allyl isothiocyanate 、 TBARS 、 Internal medicine 、 Very low-density lipoprotein 、 Chemistry 、 Mammary tumor
摘要: The present study aimed to investigate the dose response chemopreventive potential of allyl isothiocyanate (AITC) against 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. Mammary tumor was by a single DMBA (25 mg/rat) injected subcutaneously near gland. We observed reduced body weight and increased total number tumors, incidence volume DMBA-induced also decreased antioxidant status (SOD, CAT, GPX GSH) lipid peroxidation (TBARS LOOH) plasma tissues. Increased levels CYP450, Cyt-b5 phase II (GST GR) biotransformation enzymes noticed liver tissues Further, profile (TC, TG, PL FFA) lipoprotein (LDL VLDL) were noticed. Whereas, level HDL FFA tissue. Oral administration AITC different doses (10, 20 40 mg/kg bw) inhibited restored biochemical markers. Biochemical findings are supported histopathological studies. These results suggested that at bw significantly exert carcinogenesis.
elsevier.com
sci-hub.se 参考文章(68)
Martha H. Stipanuk, Biochemical and Physiological Aspects of Human Nutrition ,(2000)
William H. Habig, Michael J. Pabst, William B. Jakoby, Glutathione S-Transferases Journal of Biological Chemistry. ,vol. 249, pp. 7130- 7139 ,(1974) , 10.1016/S0021-9258(19)42083-8
Gary D. Stoner, Elaine M. Daniel, Anthony J. Galati, Young-Hun Heur, Diana T. Morrissey, Steven A. Wagner, Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus. Cancer Research. ,vol. 51, pp. 2063- 2068 ,(1991)
P N Viswanathan, Poonam Kakkar, Ballabh Das, A modified spectrophotometric assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics. ,vol. 21, pp. 130- 132 ,(1984)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Lowell B Foster, Ralph T Dunn, Stable Reagents for Determination of Serum Triglycerides by a Colorimetric Hantzsch Condensation Method Clinical Chemistry. ,vol. 19, pp. 338- 340 ,(1973) , 10.1093/CLINCHEM/19.3.338
Tsuneo Omura, Ryo Sato, The Carbon Monoxide-binding Pigment of Liver Microsomes Journal of Biological Chemistry. ,vol. 239, pp. 2370- 2378 ,(1964) , 10.1016/S0021-9258(20)82244-3
Anthony F. Trombino, Richard I. Near, Raymond A. Matulka, Shi Yang, Laurie J. Hafer, Paul A. Toselli, Dong W. Kim, Adrianne E. Rogers, Gail E. Sonenshein, David H. Sherr, Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 Breast Cancer Research and Treatment. ,vol. 63, pp. 117- 131 ,(2000) , 10.1023/A:1006443104670
Il Shik Shin, Hideki Masuda, Kinae Naohide, Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori International Journal of Food Microbiology. ,vol. 94, pp. 255- 261 ,(2004) , 10.1016/S0168-1605(03)00297-6
Anika Eva Wagner, Christine Boesch-Saadatmandi, Janina Dose, Gerhard Schultheiss, Gerald Rimbach, Anti-inflammatory potential of allyl-isothiocyanate – role of Nrf2, NF-κB and microRNA-155 Journal of Cellular and Molecular Medicine. ,vol. 16, pp. 836- 843 ,(2012) , 10.1111/J.1582-4934.2011.01367.X