Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.

摘要: Background Ischemic brain injury is associated with neuroinflammatory response, which essentially involves glial activation and neutrophil infiltration. Transcription factors nuclear factor-κB (NF-κB) signal transducer activator of transcription 3 (STAT3) contribute to ischemic processes secondary by releasing proinflammatory mediators. Kaempferol-3-O-rutinoside (KRS) kaempferol-3-O- glucoside (KGS) are primary flavonoids found in Carthamus tinctorius L. Recent studies demonstrated that KRS protected against injury. However, little known about the underlying mechanisms. Flavonoids have been reported antiinflammatory properties. Herein, we explored effects KGS a transient focal stroke model.